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The Lehigh Valley International Airport, which is served by Allegiant, American Airlines, Delta, and United, is about 15 miles from the DeSales University campus. By bus: The Allentown Bus Terminal and Bethlehem Bus Terminal are served by Greyhound and Trans-Bridge. The Hellertown Park and Ride is served by Trans-Bridge.

From the south (Philadelphia and South Jersey): Take I-76 West through Philadelphia to I-476, the Northeast Extension of the Pennsylvania Turnpike, to Exit 32/44 (Quakertown). Turn left onto Route 663 North toward Quakertown, turn left onto Route 309 North, and proceed 8 miles to the intersection of Route 309 and Route 378. At the intersection bear right and follow Route 378 North to Preston Lane. Make a right on Preston Lane to campus, and follow to Landis Mill Road. Turn right and take Landis Mill Road to Station Ave. Turn left onto Station Ave. From the Baltimore / D.C. Area: Follow I-95 North through Delaware. After entering Pennsylvania, take Route 476 West after Chester. Follow Route 476 to I-476, the Northeast Extension of the PA Turnpike, follow directions from Philadelphia. From the west (Harrisburg and Southcentral PA): Take Route 81 North and proceed East on I-78 to Route 309 South (Exit 60). Once on Route 309, stay in the right lane and use the jug handle to turn left onto Center Valley Parkway. Go approximately 2 miles then make a right on 378 South. Travel approximately 2 miles to Preston Lane. Make a left on Preston Lane and follow to Landis Mill Road. Turn right and take Landis Mill Road to Station Ave. Turn left onto Station Ave. From the north (Scranton and North): Take I-476, the Northeast Extension of the Pennsylvania Turnpike, to Exit 33/56 (Lehigh Valley). Follow Route 22 East from the interchange exit for 1/8 mile to Route 309 South (direction of Quakertown). In a few Route 309 joins with I-78 East. Continue south on this combined road until Route 309 branches off toward the south at Exit 60. Once on Route 309, stay in the right lane and use the jug handle to turn left onto Center Valley Parkway. Go approximately 2 miles then make a right on 378 South. Travel approximately 2 miles to Preston Lane. Make a left on Preston Lane and follow to Landis Mill Road. Turn right and take Landis Mill Road to Station Ave. Turn left onto Station Ave. From the east (Northern / Central New Jersey): Take the New Jersey Turnpike and/or Route 287 to I-78. Follow I-78 West across New Jersey and into Pennsylvania to Route 309 South (Exit 60A). Continue south on Route 309 for about 3 miles to the intersection of Route 309 and Route 378. Follow General Directions above. From New York City and Long Island: Take the Throggs Neck Bridge and follow the Cross Bronx Expressway/I-95 to the George Washington Bridge. Follow I-95 to Route 80 West. From I-80 take Route 287 South and follow directions from Northern/ Central New Jersey. From Connecticut, Boston and New England I-84 West to of CT-15 to US-5/CT-15: Follow the I-91 South exit to I-95 South or the Merritt Parkway, to I-287 South. Continue on I-287 South over the Tappan Zee Bridge to exit 15 for New Jersey. On I-287 South follow directions from Northern/Central New Jersey.

Allentown: Wingate by Wyndham (www.wingateinns.com); Bethlehem: Hotel Bethlehem (www.hotelbethlehem.com); Quakertown: Hampton Inn Quakertown (www.hamptoninn.com) Also: Allentown: Renaissance Hotels, Sleep Inn by Choice Hotels, and Staybridge Suites an IHG Hotel Bethlehem: Comfort Suites and Hampton Inn & Suites by Hilton Center Valley: Homewood Suites by Hilton and Springhill Suites by Marriott Quakertown: Springhill Suites by Marriott